Table 2. Variables that vary between scenarios^**.

Variable	Description	Levels
Intensity of transmission	Infected bites per adult per year prior to the introduction of IPTi‡	High transmission: 200
		Moderate transmission: 100
		Reference: 21
		Low transmission: 6
Treatment coverage	Proportion of malaria fevers treated	4%, 30%
Drug resistance	Frequency of 3 different genotypes	100%, 0%, 0%
		80%, 10%, 10%
		20%, 40%, 40%
		0%, 0%, 100%
Prophylactic period	Time in days that drug clears blood-stage infections for each of the 3 different genotypes †	0,0,0 days (treatment only)
		50, 10, 0 days (corresponds to SP)
		100, 20, 0 days
IPTi schedule	Age at doses	3, 4 and 9 months
		Single doses 1.5–24 months*
IPTi coverage	Proportion of eligible infants receiving all 3 IPTi doses (coverage with first, second and third dose)	89% (95%,95%,99%)
		50% (79%,79%,79%)
		100% (100%,100%,100%)

^**One variable was varied at a time. In each scenario, the variables not being evaluated were fixed at the reference levels (indicated in bold).

^‡The seasonality follows that of Namawala, Tanzania.[68] Each simulation assumes a recurring pattern of the vectoral capacity.

^†The proportion of infections cleared by the genotypes are set at 100%,100% and 50%.

^*We investigated the effect of age at dose by simulating a single IPTi dose at varying ages.