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Consequences of pilocarpine-induced SE
| P10-SE | Adult-SE | |
|---|---|---|
| Behavior | ||
| Spontaneous seizure | No | Yes2,12 |
| Anatomy | ||
| Hippocampal cell loss | No | CA1, CA3, hilar DG12 |
| Mossy fiber sprouting | No | Yes12 |
| DGN GABAR function | ||
| Current density | No change | Increased2 |
| Zolpidem augmentation | Increased | Decreased2 |
| DGN subunit mRNA expression | ||
| Total GABAR mRNA | Increased | Increased2 |
| GABAR α1-subunit | Increased | Decreased2 |
| GABAR α4-subunit | No change | Increased2 |
| GABAR δ-subunit | No change | Increased2 |
