A–E: Effects of microinjections of saline (A), muscimol (B), glycine (C), kynurenate (D), or 8-OH-DPAT (E) into the rRPa on skin cooling-evoked changes in physiological variables. Microinjection was made at the time point indicated by an arrowhead and broken line. The horizontal scale bar represents 100 sec, and vertical scale bars for BAT SNA traces represent 100 μV in (A and C), 50 μV in (B), 400 μV in (D), and 40 μV in (E). F: Location of the sites of all microinjections into and around the rRPa for the group data shown in Table 2. G: Representative view of a microinjection site into the rRPa as indicated by a cluster of fluorescent beads (arrow). The scale bar represents 0.5 mm. Abbreviations: Giα, alpha part of the gigantocellular reticular nucleus; py, pyramidal tract; RMg, raphe magnus nucleus; and ROb, raphe obscurus nucleus.