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Differentiation of selected stem/progenitor subpopulations within the Ewing’s sarcoma tumor microenvironment
| Stem/progenitor subpopulation | Differentiation into Endothelial cells | Differentiation into Pericytes | Differentiation into inflammatory cell types (do not contribute to neovessel formation) |
|---|---|---|---|
| CD34+38− | + | + | |
| CD34+45+ | + | + | |
| CD34−45+ | − | + (macrophages) | |
| Sca1+Gr1+ | + | + | |
| Sca1−Gr1+ | − | + (macrophages) | |
| VEGFR1+ (Flt1+) | − | ||
| VEGFR2+ (Flk1+) | + | + |
