TABLE 2.

TABLE 2a Location and Magnitude of Most Significant Correlations between Cholesterol Related Genetic Risk Scores, Including APOE ε4 Gene Dose Effects, and Lower Regional-to-Whole Brain CMRgl^*
Brain Region	Atlas Coordinates^†			Correlation Coefficient	P-Value⁺
	X	Y	Z
	Millimeters
Posterior Cingulate	0	−57	19	−0.31	7.9 × 10⁻⁵
Precuneus	6	−74	33	−0.29	2.0 × 10⁻⁴
Left Parietotemporal	−46	−66	42	−0.38	2.3 × 10⁻⁶
Right Parietotemporal	38	−74	35	−0.29	2.2 × 10⁻⁴
Left Frontal	−42	−2	31	−0.25	1.3 × 10⁻³

TABLE 2b Location and Magnitude of Most Significant Correlations between Cholesterol Related Genetic Risk Scores, Excluding APOE ε4 Gene Dose Effects, and Lower Regional-to-Whole Brain CMRgl
Brain Region	Atlas Coordinates^†			Correlation Coefficient	P-Value⁺
	X	Y	Z
	Millimeters
Precuneus	−2	−76	39	−0.29	2.8 × 10⁻⁴
Left Parietotemporal	−67	−32	16	−0.24	1.8 × 10⁻³
	−57	−49	30	−0.23	3.4 × 10⁻³
	−51	−62	43	−0.25	1.7 × 10⁻³
Right Parietal	63	−22	23	−0.28	3.1 × 10⁻⁴
	61	−39	41	−0.26	1.0 × 10⁻³
	57	−56	45	−0.25	1.7 × 10⁻³
Left Frontal	−48	10	36	−0.22	4.3 × 10⁻³

The data were extracted from voxels associated with the most significant correlations in each of the brain regions previously found to be associated with abnormally low CMRgl in patients with Alzheimer’s dementia (Alexander et al., 2002).

⁺

The reported significance levels are uncorrected for multiple comparisons; each of these correlations remained significant (p<0.05) after correcting for multiple comparisons in the relevant AD-related search regions.

^†

The coordinates were obtained from Talairach and Tournoux (1998). X is the distance to the right (+) or left (−) of the midline, Y is the distance anterior (+) or posterior (−) to the anterior commissure, and Z is the distance superior (+) or inferior (−) to a horizontal plane through the anterior and posterior commissures.

⁺

The reported significance levels are uncorrected for multiple comparisons; correlations in the precuneus and left frontal regions remained significant (p<0.05) after correcting for multiple comparisons in the relevant AD-related search regions.

^†