Table 1. MBD proteins bound to promoter hypermethylated CpG islands of tumour suppressor genes.
Target genes | |
---|---|
MeCP2 | RASSF1A, RARB2, GSTP1, MGMT, CDH1, CDH13, LTBP3, PARVG, COLL11A2 |
MBD1 | GSTP1, SOCS-1, COL11A2, PTPRN, FGF19, RARB2, CDH1 |
MBD2 | BRCA1, MGMT, p16INK4a, p14ARF, LTBP3, PTPRN, ER1, TIMP3, CDH1, GSTP1, PRLR, PTPN4 |
MBD3 | P21*, CHFR, PTPN4 |
MBD4 | p16INK4a, MHL1 |
p21* unmethylated CpG island.
References for the target genes are included in the text.