Table 2. Univariate and multivariate analysis of clinico-pathological parameters and TOPO-IIα as prognostic factors for overall survival in advanced ovarian cancer patients.
|
Univariate
|
Multivariatea
|
|||||
|---|---|---|---|---|---|---|
| Variable | RR1 | χ 2 | P-value | RR2 | χ 2 | P-value |
| Age (years) | ||||||
| <65 | 10 | — | — | — | ||
| >65 | 1.2 | 0.3 | 0.6 | |||
| Stage | ||||||
| III | 10 | 10 | ||||
| IV | 3.0 | 9.4 | 0.0021 | 1.96 | 7.1 | 0.008 |
| Extent of residual tumour | ||||||
| <1 cm | 10 | 10 | ||||
| >1 cm | 3.1 | 9.5 | 0.0020 | 1.63 | 1.5 | 0.22 |
| Response to treatment | ||||||
| No | 10 | 10 | ||||
| Yes | 9.7 | 35.0 | 0.0001 | 8.2 | 30.2 | 0.0001 |
| Topo-IIα percentages | ||||||
| 10 | 10 | |||||
| Continuous datab | 1.02b | 6.6 | 0.0101 | 1.02b | 3.9 | 0.0477 |
10=Reference category.
χ2 of the model=45.7; P-value=0.0001.
a
Only variables with P-value<0.20 in the univariate analysis were included in the multivariate model, RR1=unadjusted relative risk, RR2=relative risk after adjusting for all the factors listed
b
Relative risk per percentage unit of Topo-IIα increase.