Table 2. Semi-quantitative analysis of c-MYC network proteins in the oesophagus.
| Protein | Mean score of immunoreactivity | ||||
|---|---|---|---|---|---|
| S | F | BM | BD | OAC | |
| c-MYC | 1.50±0.2 | 0.50±0.3 | 2.42±0.5‡ | 4.00±0.7*‡° | 7.70±0.8*‡° |
| MAD1 | 1.00±0.4 | 1.25±0.3 | 0.54±0.3 | 1.81±0.5 | 3.97±0.6*‡° |
| MXI1 | 0.50±0.3 | 1.50±0.4 | 0.78±0.2 | 1.42±0.6 | 4.06±0.5*‡° |
| MAX | 4.33±1.3 | 2.00±1.2 | 1.90±0.3 | 3.7±0.77° | 8.00±0.69*‡° |
Immunohistochemistry for c-MYC, MAD1, MXI1 and MAX was performed on paraffin sections of normal squamous oesophageal mucosa (S), normal gastric fundus (F), Barrett's metaplasia (BM), dysplastic Barrett's (BD) and oesophageal adenocarcinoma (OAC). Immunoreactivity was scored as described in Materials and methods. The mean score is displayed ±1 s.e.m. * denotes significant change in comparison to S; ‡denotes statistical significance compared to F; ° denotes significance relative to BM, (P<0.05).