FIGURE 3.

Two distinct experimentally supported secondary structure models for HAR1 RNAs. (A) The cloverleaf-like model of the human HAR1 RNA. (B) The chimpanzee HAR1 RNA adopts a hairpin structure. The length and thickness of the symbols represent the intensity of the cleavages. Bases reactive to DMS or CMCT under native conditions are circled; weak reactivities are depicted by dotted circles. Bases modified by CMCT under semidenaturing conditions only are displayed with a green background. H, helix; IL, internal loop; L, loop.