Table 3.
Marginal structural model estimates of the effect of pillbox organizer use on adherence and viral load.
| Method | Difference in adherence,a % (95% CI) | Reduction in viral load, mean log10 copies/mLb (95% CI) | Viral load <400 copies/mL, OR b (95% CI) |
|---|---|---|---|
| G-computation | 4.5 (2.0–7.0) | 0.34 (0.08–0.60) | 1.81 (1.25–2.62) |
| IPTW | 4.1 (0.0–8.3) | 0.37 (0.05–0.69) | 1.91 (1.27–2.90) |
| Double robust | 4.1 (1.1–7.1) | 0.36 (0.09–0.63) | 1.91 (1.27–2.90) |
NOTE. IPTW, inverse probability of treatment weighted.
a
Data are for 237 individuals with 2504 person-years of follow-up (person-years of follow-up includes all person-months with data available for pillbox organizer use, all confounders, and pill count adherence). Pill count adherence percentage was calculated as the difference between the current and previous pill counts divided by the prescribed number of doses for the same period.
b
Data are for 194 individuals with 2227 person-years of follow-up (person-years of follow-up includes all person-months with data available for pillbox organizer use, all confounders, and viral load).