Table 1.

Comparison of the effects of NSAIDs on APP secretases. The decrease in BACE1 was detected under inflammatory conditions.

NSAIDs	activity	α-secretase	β-secretase	γ-secretase
Ibuprofen	PPARγ activator	↑(69)↕ (70,71)	↓ (70,90)	↓Aβ42/Aβ40 (108)
Indomethacin	PPARγ activator NFκB inhibitor	↑ (69) ↕ (71)	↓ (70,90)	↓Aβ42/Aβ40 (108)
Naproxen	PPARγ activator	?	↓ (70,90)	↕ Aβ42/Aβ40 (108)
Flurbiprofen	NFκB inhibitor	?	?	↓Aβ42/Aβ40 (54,108)
Aspirin	COX-1 inhibitor	?	↕ (90)	↕ Aβ42/Aβ40 (108)
Sulindac sulphide	COX-1 inhibitor	?	↕ (90)	↓Aβ42/Aβ40 (108)
Celecoxib	COX-2 inhibitor	?	↕ (70,90)	↑Aβ42/Aβ40 (56)
Fenofibrate	PPARα activator	?	?	↑Aβ42/Aβ40 (56)