Table 3.

Interactions of AP substituents at the wt-KF active site

Donor	Acceptor	Distance, Å
Orientation 1 wt-KF + d(TCG)-AP(AUC) (Fig. 6A)
ND′ [AP(U5)]	OD1 [D424]	3.1
	OD2 [D424]	3.0
ND′ [AP(C6)]	OG1 [T485]	3.0
Orientation 2 (Fig. 6B):
ND′ [AP(C6)]	O3′ [AP(C6)]	3.0
	O1P [AP(C6)]	3.2
Orientation 1 wt-KF + d(TT)-AP(U)-d(T) (Fig. 7A)
ND′ [AP(U3)]	OD1 [D355]	3.1
	OD2 [D424]	2.6
Orientation 2 (Fig. 7B)
ND′ [AP(U3)]	O2 [T(2)]	2.9
	OG [S658]	3.3
	O [P354]	2.9