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. 2008 Jun 30;105(27):9355–9360. doi: 10.1073/pnas.0801294105

Table 1.

Peak INa density, the percentage of late normalized to peak, and sodium channel kinetics from n experiments averaged and reported as mean ± SEM

Samples Peak INa
Activation
Inactivation
INaL
pA/pF n V1/2, mV K n V1/2, mV K n % n
SCN5A −233 ± 38 9 −40 ± 2 4 9 −77 ± 2 5 9 0.34 ± 0.09 5
SNTA-WT −238 ± 33 10 −44 ± 2 4 7 −76 ± 2 5 9 0.16 ± 0.04 9
SNTA-A390V −393 ± 39* 16 −41 ± 2 4 9 −69 ± 2* 6 15 0.62 ± 0.29 18
SNTA-A390V + l-NMMA −336 ± 37* 6 −44 ± 2 4 6 −75 ± 2 5 6 0.15 ± 0.04 4
SNTA-WT + NOR3 −400 ± 67* 12 −47 ± 1 4 11 −78 ± 1 5 12 0.31 ± 0.07 12
SNTA-WT + GSNO −427 ± 151* 5 −39 ± 2 4 3 −77 ± 3 5 5 0.54 ± 0.22* 5

The parameter fits were obtained from individual experiments with Boltzmann or exponential fits (see Materials and Methods).

*P < 0.05 versus SNTA-WT.