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. Author manuscript; available in PMC: 2008 Jul 1.
Published in final edited form as: Neuron. 2004 Sep 2;43(5):633–645. doi: 10.1016/j.neuron.2004.08.013

Figure 4. Confocal Microscopy of the Brains of Tg2576 Mice, Illustrating that Dietary DHA Depletion Increases Punctate Casapase-Cleaved Actin, which Is Associated with Reduced Drebrin.

Figure 4

Fractin (green) and drebrin (red) double labeling in the cortex of mice showing drebrin loss and fractin labeling in the cortex of Tg2576 mice fed a low n-3 PFA diet. (A) Periplaque green punctate fractin labeling in the cortex of a Tg2576 mouse on the low n-3 polyunsaturated fatty acids diet is shown against a reduced red drebrin labeling in the vicinity of the plaque and throughout the neuropil. (B) Fractin peptide blocks fractin labeling in an adjacent section from the same Tg(+) animal. (C and D) Representative examples showing no fractin labeling and no drebrin loss in the same region of cortex in Tg(−) mice on control diet (C) or on low n-3 PFA-enriched diet (D). Magnification, 500×.