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. 2008 Jul;132(1):115–129. doi: 10.1085/jgp.200809969

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© 2008 Zeng et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 6. — The mouse candidate β3b' subunit is functionally distinct from the human β3b subunit, failing to produce trypsin-sensitive inactivation of outward current. (A) Currents from α+mβ3b' subunits were activated with the indicated voltage protocol either with 0 (A1) or 10 (A2) μM cytosolic Ca²⁺. (B) Currents were acquired from the same patch after application of 0.5 mg/ml trypsin for a period sufficient to remove inactivation mediated by hβ3b subunits. (C) Currents resulting from α+hβ3b subunits are displayed, with the inset in C2 showing currents at 10 μM at higher magnification to show the rapid inactivation at positive command potentials. (D) After application of trypsin, α+hβ3b currents are markedly increased both at 0 (D1) and 10 (D2) μM, due to removal of fast block at positive activation potentials.