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. 2008 Jun 30;181(7):1107–1116. doi: 10.1083/jcb.200706171

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© 2008 Green et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 5. — PS1 FAD mutation M146V accelerates cytosolic Ca²⁺ sequestration. (A) Traces show Ca²⁺-dependent fluorescence changes (ΔF/F_o) after 300-ms hyperpolarizing pulses to induce Ca²⁺ entry through nAChR expressed in the plasma membrane obtained from control and PS1 M146V expressing oocytes. (B) Table listing fast (T1) and slow (T2) time constants of double-exponential fits to the Ca²⁺ decay data.