Table 6. Associations between Haplotypes and Individual FTND Items.

FTND Itema	p-valuesb
	Inter	All	Early	Late
1. How soon after you wake up do you smoke your first cigarette?	0.56	0.18	0.19	0.38
2. Do you find it difficult to refrain from smoking in places where it is forbidden?	0.84	0.63	0.68	0.90
3. Which cigarette would you hate most to give up, first one in the morning?	0.93	0.42	0.53	0.58
4. How many cigarettes per day did/do you smoke?	0.18	0.0001	0.0001	0.07
5. Do you smoke more frequently during the first hours after waking than during the rest of the day?	0.28	0.08	0.05	0.58
6. Do you smoke if you are so ill that you are in bed most of the day?	0.25	0.24	0.08	0.83

^a p-values for items 1 and 4 are from GLM tests in which the 4 levels of the item responses were taken to be an ordinal variable. For items 2, 3, 5 and 6, p-values are from logistic regression analyses.

^b“Inter” = the interaction between haplotype and age of onset, “All” = all subjects, “Early” = early onset smokers only, and “Late” = late onset smokers only. For GLM analyses, the p-value was obtained in a test across H_A, H_B, and H_C. For logistic regression analyses, the p-value was for the H_A vs. H_C effect.