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. 2008 Jun 30;2008:814815. doi: 10.1155/2008/814815

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Copyright © 2008 Li Ma et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Induction of LTP in the horizontal pathway required intact CaMKII signalling. (a) Normalized scaled amplitude of peak EPSCs evoked by test pulses in a layer II cell is plotted against time. Time point of application of 3.8 μM KN62 is indicated by the line. HFS at time zero led to a slight short-term potentiation (PTP) but no long-term potentiation. The inset shows two traces reflecting averaged EPSCs at baseline (pre-HFS) and at 30 minutes post-HFS. (b) Average normalized scaled amplitude of peak EPSCs across 6 cells in the presence of KN62 as indicated by the line. The value at 30 minutes post-HFS (0.8998 ± 0.0545) was significantly reduced from baseline (P < .05).