Table 1.
Histopathological changes in tissues of MRL+/+ mice treated with TCE for 48 weeks.
| Control | Treated | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sample | 1 | 2 | 3 | 4 | 5 | 6 | Avg±SEM | 7 | 8 | 9 | 10 | 11 | 12 | Avg±SEM | P value * |
| Tissue | |||||||||||||||
| Liver | 0 | 0 | 0 | 0 | 1 | 0 | 0.16±0.16 | 0 | 1 | 3 | 2 | 1 | 1 | 1.33±0.42 | < 0.05 |
| Kidney | 1 | 1 | 1 | 1 | 2 | 2 | 1.33±0.21 | 3 | 3 | 2 | 3 | 3 | 2 | 2.66±0.21 | < 0.05 |
| Lung | 0 | 1 | 1 | 0 | 1 | 0 | 0.5±0.22 | 1 | 1 | 2 | 3 | 3 | 1 | 1.83±0.40 | < 0.05 |
| Pancreas | 0 | 2 | 1 | 0 | 1 | 2 | 1.00±0.36 | 2 | 2 | 1 | 3 | 3 | 0 | 1.83±0.47 | n.s |
See methods for histological scoring.
*
Significant when treated samples were compared to age-matched controls by ANOVA.
n.s Statistically not significant as compared to controls.