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. Author manuscript; available in PMC: 2009 Apr 1.

Published in final edited form as: Toxicol Appl Pharmacol. 2007 Dec 14;228(1):68–75. doi: 10.1016/j.taap.2007.11.031

Table 2.

Immunological (PCNA and CD3) staining in tissues of MRL+/+ mice treated with TCE for 48 weeks.

Control								Treated
CD3
Sample	1	2	3	4	5		Avg±SEM	7	8	9	10	11		Avg±SEM	P value ^*
Tissue	1	2	3	4	5		Avg±SEM	7	8	9	10	11		Avg±SEM	P value ^*
Liver	0	0	0	0	1		0.20±0.20	1	3	3	2	0		1.80±0.58	< 0.05
Kidney	1	2	1	1	1		1.20±0.20	2	3	3	2	1		2.20±0.37	< 0.05
Lung	1	1	2	2	0		1.20±0.37	3	2	2	3	1		2.20±0.37	n.s
Pancreas	0	1	0	0	0		0.20±0.20	2	1	1	3	0		1.40±0.50	< 0.05
PCNA
Sample	1	2	3	4	5	6	Avg±SEM	7	8	9	10	11	12	Avg±SEM	P value ^*
Tissue	1	2	3	4	5	6	Avg±SEM	7	8	9	10	11	12	Avg±SEM	P value ^*
Liver	0	0	1	0	0	0	0.16±0.16	0	1	2	3	3	1	1.66±0.49	< 0.05
Kidney	1	1	0	1	1	1	0.83±0.16	2	3	2	2	2	2	2.16±0.16	< 0.05
Lung	1	0	1	2	1	0	0.83±0.30	2	2	1	2	3	2	2.00±0.25	< 0.05

0 = minimal; 1 = mild; 2 = moderate; 3 = severe infiltration.

^*

Significant when treated samples were compared to age-matched controls by ANOVA.

n.s: Statistically not significant as compared to controls.