FIGURE 5.

Phosphorylation of GSK-3β is required for LiCl- and CT-1-induced but not TGF-β-induced protein synthesis and α-actin expression. GSK-3βA9 was expressed in human airway smooth muscle cells via retroviral gene transfer. A, effect of GSK-3βA9 on protein synthesis (n = 3 for each group, mean ± S.E.; ^*, p < 0.05 relative to unstimulated cells). B, effect of GSK-3βA9 on α-smooth muscle α-actin expression in the presence of GSK-3β inhibitors, TGF-β or CT-1. Results are representative of three separate experiments.