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Dual specificity inhibitors of GGTase-I and RabGGTase. A, molecular structures of dual specificity inhibitors. B, IC50 values for dual specificity inhibitors of GGTase-I, RabGGTase, and FTase. C, inhibitory effect of 25 μm P49-F5 on the in vitro activities of GGTase-I, RabGGTase, and FTase.
