TABLE 2.
Relative amounts of nonfucosylated and fucosylated GSLs in mouse models with arrests at various steps of spermatogenesis
Values are expressed as mean ± S.D.
|
Mouse model
|
Spermatogenesis arrest at stage(s)
|
Neutral GSLs
|
Anionic GSLs
|
||||
|---|---|---|---|---|---|---|---|
| Nonfucosylated | Fucosylated | Nonfucosylated | Fucosylated + GD1a | ||||
| % | % | ||||||
| XXSxrb | Spermatogonia | 79.0 ± 6.5 | 8.7 ± 1.7 | 34.9 ± 2.0 | 42.1 ± 2.7 | ||
| mshi | Spermatogonia/spermatocytes | 70.4 ± 2.1 | 19.5 ± 2.0 | 27.3 ± 3.2 | 59.2 ± 2.0 | ||
| bax−/− | Spermatogonia/spermatids | 50.3 ± 2.2 | 45.7 ± 6.4 | 36.2 ± 5.6 | 50.7 ± 5.1 | ||
| CREM−/− | Early spermatids | 11.6 ± 0.6 | 86.3 ± 0.9 | 37.0 ± 4.6 | 48.3 ± 6.1 | ||
| C57BL/6 | None | 05.1 ± 0.7 | 93.7 ± 0.4 | 25.9 ± 4.7 | 55.8 ± 6.8 | ||