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Amphipathic characteristics and Ag+ sensitivity of residues in an α-helical wheel model for the C-terminal region of the 3–4 loop. Polar or charged wild type residues are shown in blue, and hydrophobic residues are shown in black. Ag+-sensitive Cys substitutions are highlighted with red Ag+ indicating >85% inhibition and orange Ag+ indicating 66–85% inhibition.
