Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Suggested schematic diagram of possible components that mediate the up-regulation of TH protein levels following prolonged exposure to ethanol in SH-SY5Y cells. Exposure to ethanol leads to formation of the TH-HSP90 complex via cAMP/PKA, resulting in stabilization and accumulation of TH protein. GDNF, or ibogaine via GDNF, reverses this ethanol-mediated adaptation by inhibition of the association of TH with HSP90, thus down-regulating the protein stability of TH.
