Table 3.

Topological parameters of the inferred metabolic networks from the minimal gene set and natural genomes ordered from high to small size. The size of the genome is expressed by the number of protein-coding genes (p-c genes). n, Number of nodes; L, average path length; D, network diameter; C, clustering coefficient; C_r, clustering coefficient for random network.

species	p-c genes	n	L	D	C	Cr
Bradyrhizobium japonicum	8317	1282	10.20	35	0.044	0.00150
Streptomyces coelicolor	8154	1119	10.10	29	0.064	0.00174
Mesorhizobium loti	7272	1209	9.71	33	0.055	0.00165
Anabaena sp.	6131	970	9.76	29	0.041	0.00192
Nocardia farcinica	5936	1089	9.79	30	0.047	0.00174
Agrobacterium tumefaciens (w)	5402	1147	9.45	33	0.056	0.00171
Escherichia coli (CFT073)	5379	1120	10.20	34	0.075	0.00201
Escherichia coli (K-12)	4237	1215	10.30	35	0.067	0.00570
Mycobacterium tuberculosis	3991	1139	9.98	31	0.051	0.00167
Clostridium acetobutylicum	3848	784	9.56	25	0.061	0.00246
Synechocystis sp.	3264	918	10.50	30	0.044	0.00192
Brucella melitensis	3198	1197	8.54	31	0.049	0.00161
Lactobacillus plantarum	3059	864	9.64	26	0.067	0.00220
Haemophilus influenzae (d)	1657	775	10.00	30	0.065	0.00250
Prochlorococcus marinus	1760	844	10.50	30	0.045	0.00210
Wolbachia (Bma)	1195	516	8.76	28	0.075	0.00321
Rickettsia prowazekii	886	517	8.41	24	0.042	0.00299
Tropheryma whipplei	839	426	11.60	43	0.027	0.00475
Wigglesworthia brevipalpis	617	561	11.40	35	0.035	0.00308
Blochmannia floridanus	583	634	8.47	26	0.046	0.00273
Buchnera aphidicola	504	443	7.76	25	0.042	0.00395
Mycoplasma genitalium	484	207	7.49	23	0.043	0.00826
Minimal gene set	208	165	5.34	18	0.031	0.00977