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. Author manuscript; available in PMC: 2008 Jul 1.
Published in final edited form as: J Nat Prod. 2008 Jan 15;71(2):199–207. doi: 10.1021/np0705763

Figure 1.

Figure 1

Mithramycin and its derivatives induced apoptosis in breast cancer cells. Breast cancer cells (MCF-7, 15 μM; MDA-231, 20 μM) were treated with mithramycin and derivatives 1-4. Apoptotic cells were scored after 24 h by the TUNEL (=terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling) assay and confocal microscopy. The baseline apoptosis in the untreated group was normalized with data on the treated group. The data shown are representative of the combined means ± standard error from three independent experiments.