Figure 1.

Effects of the various doses of mirtazapine on the apnea hypopnea index (AHI), compared with placebo. Estimates of the end of treatment AHI are derived from mixed-model estimates. Squares indicate the mean (bars = 95% confidence intervals) effects for each dose. Stars indicate significant worsening of the AHI, compared with placebo, adjusted for each patient's baseline value (P < 0.05) with doses of 15 mg and 30 mg. The point estimate of the AHI from the diagnostic sleep studies is included for comparison to show that placebo was not associated with a worsening of sleep apnea.