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. Author manuscript; available in PMC: 2009 Apr 15.
Published in final edited form as: Bioorg Med Chem. 2008 Feb 14;16(8):4661–4669. doi: 10.1016/j.bmc.2008.02.033

Scheme 1.

Scheme 1

Synthesis of fluorinated phenethylamine derivative 3.a

a Reagents and conditions: (a) EtNO2, c-hexNH2, HOAc, 91%; (b) NaBH4, BF3·OEt, 77%; (c) (CF3CO)2O, Et3N, 66%; (d) Br2, Ag2SO4, H2SO4, 44%; (e) NaOH, H2O/MeOH, 50%.