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RIG-I and MDA5 specifically bind to short and long poly I:C. (A) Complex of indicated poly I:C and protein (MDA5 or RIG-I) was observed by AFM. Height is on a scale from 0 to 4 nm, with a low area depicted in dark brown and a higher area depicted in brighter color. Scale area, 500 nm. Bars, 100 nm. Those are representative images from several pictures. (B and C) Statistical height analyses of molecules corresponding to pictures in A.
