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. 2008 Jul 7;205(7):1621–1634. doi: 10.1084/jem.20071365

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© 2008 GeurtsvanKessel et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 5. — Effect of conditional depletion of langerin⁺ DCs cells during influenza infection. Langerin-DTR Tg mice received an i.t. injection of DT on day −1, followed by X-31 i.n. infection. (A) Efficient depletion of MHCII⁺CD11c DCs in lung after DT treatment. Numbers indicate percentages of live cells within the gate. (B) Body weight after influenza infection. A weight loss of >20% represents a sublethal infection. (C) Virus-specific CTL response in spleen and lung measured by Flu_peptide/H-2D^b tetramer (TM) staining. (D) Viral titers measured in lung tissue after influenza X-31 infection. Virus is normally cleared completely at 8 dpi. The values are representative of five mice per group and are expressed as mean ± SEM. Similar results were obtained from at least two separate experiments. *, P < 0.05; **, P < 0.01. nd, nondetectable.