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. 2008 Jul 7;205(7):1621–1634. doi: 10.1084/jem.20071365

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© 2008 GeurtsvanKessel et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 6. — Infection parameters after influenza in mice depleted of pDCs. Mice received three i.p. injections of the depleting mAb 120G8 before infection with influenza on day 0. (A) Efficient depletion of lung pDCs after 3 d of 120G8 i.p. treatment compared with PBS treatment. (B) Body weight after infection. (C) Virus-specific CTL responses in spleen and lung cell suspensions, as measured by Flu_peptide/H-2D^b tetramer staining. (D) IFN-γ levels in supernatants of MLN cell cultures restimulated with anti-CD3 antibody. (E) Viral titers in lung after influenza infection. (F) IFN-α levels in BAL fluid. The values are representative of five mice per group and are expressed as mean ± SEM. Similar results were obtained from at least two separate experiments. *, P < 0.05; **, P < 0.01.