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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Pharmacol Biochem Behav. 2008 Apr 4;90(3):409–415. doi: 10.1016/j.pbb.2008.03.024

Figure 2.

Figure 2

Effects of precipitated withdrawal from nicotine delivered via osmotic minipump on ICSS thresholds in mice. A, data are expressed as mean (±S.E.M.) percentage change of reward thresholds during the baseline period (see Methods) or after administration of mecamylamine (2 mg/kg, IP), in mice receiving chronic saline or nicotine (24 mg/kg/day, free-base) delivered via osmotic minipump. B, data are expressed as mean (±S.E.M.) percentage change of response latencies during the baseline period (see Methods) or after administration of mecamylamine (2 mg/kg, IP), in mice receiving chronic saline or nicotine (24 mg/kg/day, free-base) delivered via osmotic minipump. *** P < 0.001, different from control (saline-treated) mice after administration of mecamylamine, Bonferroni post-test after significant interaction effect in two-way repeated-measures ANOVA.