Table II.

Individual subjects and concentrations of M1 at time intervals over the 3 dosage ranges

Patient	1	2	3	4	5	6
Dose = 1 mg/kg
Time (min)	ng/mL	ng/mL	ng/mL	ng/mL	ng/mL	ng/mL
1	24.2	31.3	0	0	48.2	23.3
2	25.6	23	n.s	0	34.5	28.4
5	18.9	18.8	22.6	0	30.5	20.2
10	38.9	16	18.7	136.1	30.7	24.1
20	20.8	15.4	13.4	0	24	21.2
40	14.5	14.4	10.2	0	18.9	11.6
60	15.6	11.2	0	0	14.9	41.9
120	0	0	0	0	0	0
240	0	0	0	0	0	0
Dose = 2 mg/kg
Time (min)	ng/mL	ng/mL	ng/mL	ng/mL	ng/mL	ng/mL
1	40.4	43.1	59.6	50.3	53.4	126.7
2	31.1	32.5	58.1	36.1	56.2	46.7
5	19.4	35.1	52.9	28.3	32.8	38.1
10	26.2	31	29.3	0	32.7	29.1
20	29.3	29.7	—	21.9	33.4	0
40	17.5	24.1	24.5	14.5	42.8	14.8
60	21	20.7	16.8	11.6	20.6	0
120	10.9	17.2	0	0	0	0
240	0	11.1	0	0	0	0
Dose = 4 mg/kg
Time (min)	ng/mL	ng/mL	ng/mL	ng/mL	ng/mL	ng/mL
1	0	0	35.3	0	135.1	0
2	0	0	—	0	64.4	0
5	78.3	0	23.4	0	80.4	0
10	0	0	26.4	0	51.1	0
20	0	0	41.7	0	40.8	0
40	0	0	15	0	30.9	0
60	0	0	25.4	0	45	0
120	0	0	21	0	18.2	0
240	0	0	0	0	0	0