Table III.
Mean +/− standard deviation of tramadol following 2 intravenous dosages: 1, 2, and 4 mg/kg
| IV dosage
|
|||
|---|---|---|---|
| Variable | 1 mg/kg | 2 mg/kg | 4 mg/kg |
| A | 820.28 +/− 922.07 | 1665.5 +/− 1713.9 | 4664.0 +/− 6992.0 |
| B | 225.15 +/− 69.45 | 510.46 +/− 140.01 | 858.11 +/− 328.8 |
| Alpha | 0.21 +/− 0.24 | 0.5 +/− 0.47 | 0.51 +/− 0.67 |
| Beta | 0.01 +/− 0.0 | 0.01 +/− 5.16 × 10−3 | 0.01 +/− 0.0 |
| Vd (mL/kg) | 3.23 +/− 0.69 | 3.35 +/− 0.6 | 3.42 +/− 0.47 |
| Cl (mL/min/kg) | 36.15 +/− 10.03 | 45.12 +/− 15.59 | 35.58 +/− 2.96 |
| α T1/2 (h) | 0.13 +/− 0.1 | 0.07 +/− 0.07 | 0.12 +/− 0.12 |
| β; T1/2 (h) | 1.28 +/− 0.32 | 1.04 +/− 0.42 | 1.36 +/− 0.36 |
| AUC (ng/h)/mL/L | 492.23 +/− 141.75 | 820.35 +/− 297.45 | 1884.1 +/− 155.31 |
A — intercept of the distribution phase; B — intercept of the elimination phase; Alpha — distribution rate constant; Beta — elimination rate constant; Vd — volume of distribution; Cl — clearance; α(α T1/2) — plasma distribution half-life; β(β T1/2) — plasma clearance half-life; AUC — area under the plasma concentration curve.