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. 1999 Dec 7;96(25):14276–14281. doi: 10.1073/pnas.96.25.14276

Figure 1.

Figure 1

(a) Inhibition of telomerase activity by 2′-O-MeRNA oligomers delivered into HME50-5E cells by using FuGENE6 lipid, measured 3 days after transfection. Similar results were observed on introduction of 2′-O-MeRNA oligomers into HME50-hTERT cells and on introduction of 2′-O-MeRNA or PNA oligomers into DU145 cells. (b) Inhibition of telomerase activity in HME50-5E and DU145 cells by 2′-O-MeRNA and PNA oligomers as detected by the TRAP assay. HME50-5E and DU145 cells were collected 1 and 3 days after transfection with 2′-O-MeRNA or PNA oligomers. Telomerase activity was quantitated as described (38).