. Author manuscript; available in PMC: 2008 Jul 2.

Published in final edited form as: Org Lett. 2005 Dec 8;7(25):5709–5712. doi: 10.1021/ol052498l

Table 3.

Cytotoxicity and Antimicrobial Activity of Compounds Isolated from Mitrephora glabra

	IC₅₀ values (μg/mL)^a				minimal inhibitory concentration (μg/mL)^b

compound	KB	MCF-7	H460	SF-268	M. luteus	M. smegmatis	S. cerevisiae	A. niger
1	8.0	15.7	23.3	30.9	125	63	63	63
2	7.0	Inactive	Inactive	Inactive	88	88	88	88
3	Inactive^c	Inactive	Inactive	Inactive	63	31	31	63
4	Inactive	Inactive	Inactive	Inactive	19	75	75	75
positive controls^d	0.005 (camptothecin)	0.025 (camptothecin)	0.002 (camptothecin)	0.021 (camptothecin)	0.1 (ampicillin)	0.2 (kanamycin)	25 (amphotericin B)	25 (amphotericin B)

KB: human oral epidermoid carcinoma; MCF-7: human mammary adenocarcinoma; H460: human non-small cell (large cell) lung carcinoma; SF-268: human astrocytoma. IC₅₀ values are determined as the concentration required to reduce cellular staining with sulforhodamine B by 50% relative to untreated controls following 72 h of continuous exposure.¹⁷

Minimal inhibitory concentration is the lowest concentration of compound completely inhibiting growth (as turbidity) expressed in μg/mL.¹⁷

Inactive = IC₅₀value > 30 μg/mL.

Average values.