Table 2.

Quantitation of CXCL1 and CXCL2 in brain and serum of healthy mice

Ligand*/genotype	Cxcr2+/+	Cxcr2−/−	Fold change
CXCL1
Brain	86 ± 19	362 ± 200†	4
Blood	325 ± 39	5691 ± 2000‡	17
CXCL2, blood	ND	464 ± 136	> 100

Levels of the CXC chemokine, CXCL1 were measured by ELISA in brain supernatants (n = 6 mice per group) and serum (n = 9 mice per group). CXCL2 was measured in serum (n = 4 mice per group).

^*Data represent the mean ± SD of CXCL1 amount in pg/mg protein. Brain and circulating levels were significantly higher in Cxcr2^−/− mice compared with wild-type mice.

^†P = .008.

^‡P < .001.