Table 3.

PrP regions including amyloidogenic determinants according to [21]

Segments of PrP sequence	Mutations	Modification sites
SNQNNFVHDCVNITIKQHTF	D178N, V180I, T183A	N-Glycozylation 181–184 Kinase C 183–185 Disulfide 179–214
KMMERVVEQMCITQYER	R208H, V210I, E211Q, Q212P, Q217R	Kinase II 216–219 Disulfide 179–214
SPPVILLISFLIFLIVG	P238S

Column 1: Human prion protein (P04156), segments 170–188, 204–220, and 237–253. Underlined amino acids are those of column 2. Columns 2 and 3: Pathologenic point mutations and potential protein modifications according to UniProtKB.