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. Author manuscript; available in PMC: 2008 Jul 3.
Published in final edited form as: Annu Rev Pharmacol Toxicol. 2007;47:469–512. doi: 10.1146/annurev.pharmtox.47.120505.105225

Figure 4.

Figure 4

Effects of chromophore supplementation and gene therapy on vision in rpe65−/− and lrat−/−knockout mice. (a) Single-cell recording stimulus response families of rpe−/− mice supplemented with 9-cis-RAL compared with rpe+/+ mice. (b) High performance liquid chromatography (HPLC) analysis of retinoids present in the eyes of lrat−/− mice treated with 9-cis-retinyl acetate. The presented results were reproduced from References 155 and 157.