TABLE 2.
Biomonitoring: inhalation toxicity study
| Parameter | Sex | Sham | 1R4F-low | 1R4F-medium | 1R4F-high | EHC-CaCO3 | EHC-AMP |
|---|---|---|---|---|---|---|---|
| Respiratory frequency (1/min) | M | 129 ± 8 | 152 ± 8* | 128 ± 5 | 121 ± 4 | 131 ± 9 | 125 ± 10 |
| F | 119 ±10 | 146 ± 10 | 111 ± 7 | 96 ± 6 | 100 ± 4 | 141 ± 5 | |
| Average inspiratory flow (ml/sec) | M | 8.7 ± 0.4 | 6.2 ± 0.4* | 5.4 ± 0.6* | 5.9 ± 0.4* | 6.0 ± 0.4* | 6.7 ± 0.6* |
| F | 7.1 ± 0.6 | 5.7 ± 0.6 | 4.7 ± 0.5* | 3.9 ± 0.6* | 4.7 ± 0.4* | 6.3 ± 0.4 | |
| COHb (%) | M | 0.64 ± 0.03 | 13.94 ± 0.30* | 19.5 ± 0.53* | 26.00 ± 0.65* | 4.65 ± 0.29* | 2.27 ± 0.07* |
| F | 0.85 ± 0.03 | 12.82 ± 0.33* | 20.38 ± 1.21* | 25.27 ± 0.57* | 4.91 ± 0.40* | 1.52 ± 0.06* | |
| Recovery of inhaled nicotine (%) | M | — (n.d.) | 73.2 ± 5.3 | 61.5 ± 6.8 | 76.0 ± 7.3 | 63.7 ± 5.7 | 60.4 ± 7.3 |
| F | — (n.d.) | 68.1 ± 9.1 | 88.3 ± 9.4 | 75.5 ± 3.9 | 68.4 ± 11.4 | 69.6 ± 4.7 |
Values represent means ± standard error.
*
Statistically significantly different from sham, p ≤ 0.05.
n.d.: not determined.