TABLE 3.
Body weight and hematology after 90 days of exposure: inhalation toxicity study
| Groups | EECRs | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Parameter | Sex | Sham | 1R4F-Iow | lR4F-medium | lR4F-high | EHC-CaCO3 | EHC-AMP | EHC-CaCO3 | EHC-AMP |
| Body weight (g) | M | 395.8 ± 6.7 | 331.7 ± 11.8* | 339.7 ± 9.9* | 310.3 ± 10.1* | 309.0 ± 7.7* | 349.9 ± 10.8* | 1.99 | 0.61 |
| F | 212.4 ± 3.9 | 199.4 ± 3.8 | 204.5 ± 4.7 | 207.7 ± 5.2 | 202.1 ± 4.4 | 200.8 ± 5.9 | – | – | |
| Platelet count (109/l) | M | 977 ± 42 | 934 ± 43 | 817 ± 49* | 862 ± 32 | 851 ± 29 | 818 ± 38 | 1.62 | 2.26 |
| F | 921 ± 58 | 901 ± 38 | 886 ± 37 | 812 ± 23 | 880 ± 36 | 906 ± 26 | – | – | |
| Neutrophils in blood (109/l) | M | 0.87 ± 0.16 | 1.14 ± 0.19 | 1.48 ± 0.20 | 1.90 ± 0.30* | 1.39 ± 0.13 | 1.34 ± 0.36 | 1.24 | 1.21 |
| F | 0.45 ± 0.05 | 0.74 ± 0.10 | 1.09 ± 0.14* | 1.30 ± 0.13* | 1.04 ± 0.10* | 0.64 ± 0.08* | 1.34 | 0.61 | |
| Lymphocytes in blood (109/l) | M | 6.32 ± 0.54 | 3.74 ± 0.64* | 3.83 ± 0.54* | 3.91 ± 0.41* | 5.23 ± 0.56 | 4.82 ± 0.82 | – | – |
| F | 3.61 ± 0.45 | 3.33 ± 0.30 | 3.56 ± 0.42 | 3.75 ± 0.48 | 2.67 ± 0.22 | 3.79 ± 0.55 | – | – | |
Values represent means ± standard error.
*
Statistically significantly different from sham, p ≤ 0.05.
EECRs were calculated on an equal TPM basis.
–: no EECR calculated because data did not fit the criteria.