TABLE 4.
Clinical chemistry after 90 days of exposure: inhalation toxicity study
| Groups | EECRs | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Parameter | Sex | Sham | 1R4F-Iow | lR4F-medium | lR4F-high | EHC-CaCO3 | EHC-AMP | EHC-CaCO3 | EHC-AMP |
| Total cholesterol (mmol/1) | M | 2.0 ± 0.1 | 1.5 ± 0.1* | 1.5 ± 0.1* | 1.6 ± 0.1* | 1.7 ± 0.1 | 1.8 ± 0.1 | – | – |
| F | 2.3 ± 0.2 | 1.6 ± 0.2* | 1.5 ± 0.1* | 1.1 ± 0.1* | 1.2 ± 0.1* | 1.8 ± 0.1* | 1.75 | 0.68 | |
| Triglycerides (mmol/1) | M | 0.8 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.9 ± 0.1 | 0.8 ± 0.1 | 0.9 ± 0.1 | – | – |
| F | 1.1 ± 0.3 | 0.7 ± 0.1 | 0.5 ± 0.1* | 0.4 ± 0.0* | 0.5 ± 0.0* | 0.8 ± 0.2 | 1.25 | 0.62 | |
| ALT (UA) | M | 55.2 ± 12.9 | 50.8 ± 3.2 | 54.3 ± 4.6 | 63.1 ± 9.1 | 43.4 ± 2.5 | 43.9 ± 4.0 | – | – |
| F | 32.1 ± 1.8 | 34.6 ± 1.8 | 48.0 ± 4.2* | 54.6 ± 3.0* | 45.6 ± 3.1* | 44.2 ± 5.2 | 1.36 | 1.33 | |
| AP(UA) | M | 193.4 ± 16.0 | 217.2 ± 12.5 | 214.5 ± 17.6 | 275.9 ± 36.5 | 260.4 ± 35.8 | 212.5 ± 19.2 | – | – |
| F | 108.8 ± 6.9 | 158.3 ± 11.0 | 197.4 ± 23.2* | 213.7 ± 14.6* | 219.9 ± 19.1* | 132.2 ± 11.0 | 1.84 | 0.38 | |
| Protein (g/1) | M | 61.4 ± 0.8 | 57.7 ± 1.3* | 59.2 ± 1.0 | 61.3 ± 1.0 59.9 ± 1.3 | 59.9 ± 1.3 | 62.4 ± 1.1 | – | – |
| F | 66.9 ± 1.9 | 61.6 ± 1.5* | 60.1 ± 1.1* | 55.7 ±1.1* | 56.7 ± 0.5 | 61.9 ± 2.6 | 1.71 | 0.98 | |
Values represent means ± standard error.
*
Statistically significantly different from sham, p ≤ 0.05.
EECRs were calculated on an equal TPM basis.
–: no EECR calculated because data did not fit the criteria.
AP: alkaline phosphatase activity.
ALT: alanine aminotransferase activity.