Table 3.
Summary of baseline-corrected QTc and peak plasma levels in the anaesthetized guinea-pig
| Dose (mg kg−1) | Peak plasma level (μm)(n) | Baseline-corrected QTc (Δ%)(n) |
|---|---|---|
| Group A | ||
| Amiodarone (vehicle 1) | ||
| 5 | 6.0±1.4 (4) | 8.0±5.1 (5) |
| 10 | 58.3±9.6 (3) | 13.0±5.2 (4) |
| 20 | 240±52.7 (5) | 6.9±3.8 (5) |
| Cisapride (vehicle 2) | ||
| 0.1 | 0.037±0.023 (4) | 8.5±3.6 (5) |
| 0.3 | 0.129±0.032 (4) | 6.6±2.4 (5) |
| 1 | 0.496±0.085 (5) | 18.2±1.9 (5) |
| Droperidol (vehicle 1) | ||
| 0.03 | 0.55±0.07 (3) | 2.1±3.2 (5) |
| 0.1 | 0.62±0.05 (5) | 6.7±2.3 (5) |
| 0.3 | 1.21±0.34 (5) | 19.1±4.8 (5) |
| Haloperidol (vehicle 3) | ||
| 0.01 | 0.010±0.003 (3) | 1.5±0.8 (5) |
| 0.1 | 0.113±0.012 (4) | 4.3±1.2 (5) |
| 1 | 0.712±0.137 (5) | 15.8±3.6 (5) |
| Quinidine (vehicle 2) | ||
| 3 | 6.2±0.08 (3) | 8.5±1.5 (5) |
| 10 | 27.8±8.0 (5) | 13.7±2.9 (5) |
| 30 | Not determined | 15.6±4.9 (4) |
| Sotalol (vehicle 1) | ||
| 1 | 18.2±1.5 (5) | 18.1±5.3 (5) |
| 3 | 41.3±4.8 (4) | 10.9±1.8 (5) |
| 10 | 145.9±16.6 (5) | 18.9±6.6 (5) |
| Sparfloxacin (vehicle 4) | ||
| 3 | 23.5±4.2 (3) | 6.6±0.9 (5) |
| 10 | 80.4±9.1 (5) | 9.8±1.7 (5) |
| 30 | 159.4±22.4 (4) | 20.0±3.3 (5) |
| Terfenadine (vehicle 3) | ||
| 0.3 | 0.23±0.03 (3) | 2.8±0.8 (5) |
| 1 | 1.28±0.07 (3) | 8.0±2.0 (5) |
| 3 | 3.04±±1.07 (3) | 11.7±1.2 (5) |
| Group B | ||
| Moxifloxacin (vehicle 3) | ||
| 1 | 2.08±0.28 (4) | 0.9±1.7 (5) |
| 5 | 30.6±7.2 (4) | 11.2±3.0 (5) |
| 10 | 80.5±4.0 (5) | 18.3±4.4 (5) |
| Tamoxifen (vehicle 3) | ||
| 3 | 3.8±0.8 (4) | 2.2±1.0 (5) |
| 10 | 10.5±2.1 (5) | 10.2±3.9 (5) |
| 30 | 60.0±20.0 (5) | 8.4±1.4 (5) |
| Ziprasidone (vehicle 1) | ||
| 0.1 | 1.1±0.2 (4) | 4.9±2.0 (5) |
| 0.3 | 1.2±0.1 (2) | 7.0±1.9 (5) |
| 1 | 4.0±2.2 (2) | 9.1±1.0 (5) |
| Group C | ||
| Amoxicillin (vehicle 3) | ||
| 3 | 4.8±0.5 (5) | 4.2±2.0 (5) |
| 10 | 14.6±1.4 (4) | 4.4±1.6 (5) |
| 20 | 30.3±2.5 (5) | 3.9±0.3 (5) |
| Aspirin (vehicle 1) | ||
| 1 | 31.1±2.3 (5) | 0.5±0.8 (5) |
| 3 | 74.6±2.1 (5) | 1.3±0.6 (5) |
| 10 | 468±78 (4) | 2.5±1.8 (5) |
| Captopril (vehicle 1) | ||
| 3 | 57.8±1.6 (2) | 0.0±0.9 (5) |
| 10 | 142±15 (2) | −1.3±1.4 (5) |
| 30 | 313±112 (2) | −6.0±1.9 (4) |
| Propranolol (vehicle 1) | ||
| 0.3 | 0.50±0.03 (3) | −1.6±1.2 (5) |
| 1 | 1.84±0.41 (3) | 2.7±1.3 (5) |
| 3 | 4.65±0.40 (5) | 1.1±1.4 (5) |
| Verapamil (vehicle 1) | ||
| 0.25 | 0.48±0.04 (4) | −0.9±0.7 (5) |
| 0.5 | 0.73±0.03 (2) | −2.3±1.7 (5) |
| 1 | 1.97±0.37 (4) | −0.4±2.0 (5) |
Abbreviation: QTc, heart rate corrected QT interval of the ECG.