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Effects of vehicles on baseline-corrected QTc in the anaesthetized guinea pig
| Vehicles | Composition | Baseline-corrected QTc (Δ%)(n) |
|---|---|---|
| 1 | 0.9% NaCl | 1.3±0.8 (5) |
| 2 | 15% HP-β-cyclodextrin in 25 mM methanesulphonic acid | 1.5±0.1 (5) |
| 3 | 5% DMSO–10% SBE–cyclodextrin in 5 mM methanesulphonic acid | 1.6±0.8 (5) |
| 4 | 10 mg mL−1 lactic acid in 5% dextrose in water | 0.4±1.2 (5) |
Abbreviation: QTc, heart rate corrected QT interval of the ECG.
