Table 3.
Adjusted* hazard ratios (HRs) of future CHD and ischemic stroke in initially healthy women according to tertile of various lipid ratios at baseline.
| Biomarker | Tertile 1 | Tertile 2 | Tertile 3 | Ptrend |
|---|---|---|---|---|
| Lipid Ratios | ||||
| Total cholesterol to HDL-C (range) | <3.61 | 3.61−4.77 | >4.77 | |
| Ischemic stroke events | 22 | 36 | 74 | |
| HR (95% CI) | 1.00 | 1.22 (0.70−2.11) | 1.95 (1.16−3.26) | 0.004 |
| CHD events | 28 | 86 | 222 | |
| HR (95% CI) | 1.0 | 2.05 (1.32−3.17) | 4.20 (2.79−6.32) | <0.0001 |
| LDL-C to HDL-C (range) | <2.13 | 2.13−2.99 | >2.99 | |
| Ischemic stroke events | 24 | 36 | 72 | |
| HR (95% CI) | 1.00 | 1.22 (0.72−2.07) | 1.77 (1.08−2.90) | 0.01 |
| CHD events | 30 | 95 | 211 | |
| HR (95% CI) | 1.0 | 2.31 (1.51−3.53) | 4.04 (2.71−6.02) | <0.0001 |
| Apo B100 to Apo A-I (range) | <0.61 | 0.61−0.82 | >0.82 | |
| Ischemic stroke events | 25 | 37 | 70 | |
| HR (95% CI) | 1.00 | 1.00 (0.59−1.68) | 1.42 (0.88−2.30) | 0.08 |
| CHD events | 33 | 88 | 215 | |
| HR (95% CI) | 1.0 | 1.74 (1.15−2.62) | 3.41 (2.33−4.98) | <0.0001 |
| Apo B100 to HDL-C (range) | <1.66 | 1.66−2.49 | >2.49 | |
| Ischemic stroke events | 24 | 37 | 71 | |
| HR (95% CI) | 1.00 | 1.13 (0.66−1.93) | 1.62 (0.98−2.68) | 0.03 |
| CHD events | 29 | 87 | 220 | |
| HR (95% CI) | 1.0 | 2.00 (1.30−3.07) | 3.98 (2.65−5.96) | <0.0001 |
Abbreviations: CHD, coronary heart disease; CI, confidence interval; HDL, high-density lipoprotein; HR, hazard ratio; LDL, low-density lipoprotein.
*
Adjusted for age in years, blood pressure in Framingham categories, body mass index, diabetes, current smoking status and randomized treatment assignment.