Figure 3.

The time to stabilization of the hybrid genome (heterozygosity less than 0.001) is predicted by junction density with a relatively small variance introduced by genetic drift. (A) The results of 4000 simulations, with no selection and constant population sizes between 25 and 150, can be fit by a linear model (solid line, y = 1248x − 4). Residual variance around the regression allows the estimation of a 95% confidence interval for observations (dashed line). (B–D) Point estimates of junction density predict times to stabilization of the hybrid genomes (solid black lines). Variance due to genetic drift introduces some uncertainty in estimates (dashed black lines). Uncertainty due to the sensitivity of maps to underlying junction density is substantially larger (dotted black lines).