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. Author manuscript; available in PMC: 2008 Jul 3.
Published in final edited form as: Mol Psychiatry. 2007 Jan 30;12(7):656–670. doi: 10.1038/sj.mp.4001957

Figure 2.

Figure 2

Reduction in BDNF mRNA in dorsal hippocampus with no changes in baseline activity or startle. (a) Qualitative figure showing BDNF in situ hybridization of dorsal hippocampus following a sham injection (top, −Cre) or following LV-Cre injection (bottom, + Cre). (b) Nissle-stained sections (from different experiment than (a) from hippocampi that have been infected with LV-GFP or LV-Cre. We found no discernable morphological changes with either viral infection compared to control. (c) Relative mRNA expression in dentate gyrus (DG), and CA1 and CA3 regions and the average of all regions (Avg) of dorsal hippocampus in LV-Cre (Cre)- or LV-GFP (GFP)-infected mice. (d) The estimated percentage of total area of each hippocampal region infected within the examined sections. (e) Baseline activity (%time moving) within the SR-LAB behavior box in mice that have been infected bilaterally with LV-Cre or LV-GFP. (f) Baseline acoustic startle reflex (startle amplitude) in mice that have been infected bilaterally with LV-Cre or LV-GFP (*P < 0.001).