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. Author manuscript; available in PMC: 2008 Jul 3.
Published in final edited form as: Mol Psychiatry. 2007 Jan 30;12(7):656–670. doi: 10.1038/sj.mp.4001957

Figure 5.

Figure 5

Extinction of conditioned fear is impaired in mice with dorsal hippocampus BDNF deletions. (a) Percent FPS is graphed for the first post-fear training test (pre-extinction) vs the last test (post-extinction). Mice infected with LV-GFP demonstrate significant decreases in their level of conditioned fear as measured with %FPS compared with LV-Cre-infected mice. (b) Impaired extinction of fear, measured with %FPS, is stable across multiple testing sessions. (c) Percent freezing is graphed for the first post-fear training test (pre-extinction) vs the last test (post-extinction). The percent reduction in freezing from pre- to post-extinction is significantly greater for the LV-GFP group than the LV-Cre group. (d) Impaired extinction of fear measured with freezing demonstrated across testing sessions (*P < 0.05; **P < 0.005).