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. Author manuscript; available in PMC: 2008 Jul 3.
Published in final edited form as: Annu Rev Biophys. 2008 Jun 9;37:289–316. doi: 10.1146/annurev.biophys.37.092707.153558

Figure 7.

Figure 7

(Left) The density of states (DOS) cartoonized as an energy landscape for the three-helix bundle protein F13W*: DOS (x-axis) versus the energy (y-axis). (Right) Denaturation predictions versus experiments (146). The peak free energy (here, where the DOS is minimum), typically taken to be the transition state, is energetically very close to native.